Best Oral Pain Relief Medications (Dec. 2024) - Rated by CherryPicks' Experts

At a Glance: Our Top Picks

Top 1

Anbesol Maximum Strength Oral Pain Relief Gel, Instant Pain Relief For Tootha...

9.9
CPR Score
Top 2

DenTek Instant Oral Pain Relief Maximum Strength Kit for Toothaches | 50 Count

9.8
CPR Score
Top 3

Oral Pain Relief, 0.75 Gram Packets (Box of 144)

9.7
CPR Score
Tips

We researched and analyzed dozens of Oral Pain Relief Medications reviews from different Oral Care brands, including DenTek, Orajel, Rite Aid, Blistex, Stopain, Anbesol, Benzodent, Red Cross, Safetec, LIUMY, Mavvel, Kanka, Bobfriend, Hurricaine Cherry liquid, Nyloxin And Tisserand. We've selected 28 best Oral Pain Relief Medications in the following ranking by considering price, product features, easy to use and so on.

* CherryPicks.Reviews is reader-supported, Our editor review, and recommend the best products based on extensive data analysis, if you click on the product links, we may earn a commission through qualifying products purchased.

The Best Oral Pain Relief Medications Rated by CherryPicks

Market Overview
Oral Pain Relief Medications Reviewed
  • Reviews Analyzed: 71,729 Items
  • CPR Avg. Rating: 8.6 / 10
28 Products Evaluated
  • Highest Price: $35.99
  • Lowest Price: $4.99
  • Avg. Price: $13.12
Price Disclaimer

Top 28 Oral Pain Relief Medications on Amazon (Verified You can Buy)

Anbesol Maximum Strength Oral Pain Relief Gel, Instant Pain Relief For Toothache Pain, Canker Sores, Sore Gums, Mouth Sores, Denture Pain, and Aligner Pain, ADA Accepted, 0.33 oz (packaging may vary)

Anbesol
305730225670
0.0206 Pounds

Ratings for Anbesol (CPR Score)

Seller CPR Rank Amazon Fulfilled Prime Free Shipping
Amazon.com -

Features

INSTANT PAIN RELIEF: Instant oral pain relief for mouth and gum irritation due to toothaches, canker sores, sore gums, denture pain, and minor dental procedures. Use with dentures to relieve discomfort.
MAXIMUM STRENGTH: Instant relief that takes you from ouch to ahhh! So, oral pain doesn’t hold you back. Formulated with 20% Benzocaine to offer maximum strength pain relief and instantly soothe mouth pain and dental irritation
Show More

DenTek Instant Oral Pain Relief Maximum Strength Kit for Toothaches | 50 Count

DenTek
00352
3.95 x 1.19 x 4.03 Inches
0.0 Pounds

Ratings for DenTek (CPR Score)

Seller CPR Rank Amazon Fulfilled Prime Free Shipping
Amazon.com -
Wiki Deals 53

Features

DenTek Instant Pain Relief, Advanced Kit gives instant and precise relief from oral pain and toothaches
Ergonomic handle to reach any area of the mouth gives simple, no-fingers no-mess, relief
Show More
Top 3

Oral Pain Relief, 0.75 Gram Packets (Box of 144)

Safetec
40.0 x 70.0 x 40.0 Inches
0.0006 Pounds

Ratings for Safetec (CPR Score)

Seller CPR Rank Amazon Fulfilled Prime Free Shipping
Amazon.com -
global-wholesale 7,311
Katy Med Solutions 3,234
Health & Prime 358

Orajel 4X for Toothache & Gum Pain: Severe Cream Tube 0.33oz- From Oral Pain Relief Brand

Orajel
Orajel, orajel, toothache
4.375 x 1.0 x 3.688 Inches
0.021 Pounds

Ratings for Orajel (CPR Score)

Seller CPR Rank Amazon Fulfilled Prime Free Shipping
Amazon.com -
Surprise Dealz -

Features

INSTANT PAIN RELIEF: Instant pain relief with Orajel’s unique 4X clinical strength formula to help relieve pain of the tooth and gums
4X ACTIVE INGREDIENTS: With 4 active ingredients, Orajel Cream provides fast acting and maximum strength relief when you need it most
Show More

Orajel 3X for Mouth Sores: Maximum Strength Gel Tube 0.42oz- from #1 Oral Pain Relief Brand- for Instant Pain Relief

Orajel
10310310000285
4.375 x 1.0 x 3.688 Inches
0.026 Pounds

Ratings for Orajel (CPR Score)

Seller CPR Rank Amazon Fulfilled Prime Free Shipping
Amazon.com -
Titan Earth Designs -

Features

INSTANT PAIN RELIEF: Orajel Mouth Sore Gel contains 20% Benzocaine to relieve pain from canker sores, mouth sores, cold sores and other mouth irritations
SOOTHING RELIEF: Maximum strength gel uses menthol to soothe irritated and sore gums quickly, where you need it most
Show More

Benzodent Dental Pain Relieving Cream for Dentures and Braces, Topical Anesthetic, 1 Ounce Tube

Benzodent
10041167005344
4.75 x 1.06 x 1.13 Inches
0.0625 Pounds

Ratings for Benzodent (CPR Score)

Seller CPR Rank Amazon Fulfilled Prime Free Shipping
Amazon.com -

Features

FOR DENTAL PAIN: Benzodent provides temporary relief of pain for oral discomfort caused by dentures, braces or sores, with the maximum amount of benzocaine allowed in an over the counter oral product.
LONG LASTING RELIEF: Benzodent is a thick topical cream that provides pain relief with the strength of benzocaine. The unique formula cushions & adheres to gums for pain relief that lasts for hours.
Show More

Red Cross Toothache Medication Drops

Red Cross
PPAX1236955
0.98 x 3.62 x 4.24 Inches
0.2 Pounds

Ratings for Red Cross (CPR Score)

Seller CPR Rank Amazon Fulfilled Prime Free Shipping
Amazon.com -
epharmastore 3,744
Bleam 677
HerbsPro 7,236
Celerity Arbitrators -

Features

Product of Red Cross

Orajel Maximum Strength Nighttime Toothache Pain Relief Cream - 0.25 Oz

Orajel
31854
3.75 x 3.25 x 1.0 Inches
0.0156 Pounds

Ratings for Orajel (CPR Score)

Seller CPR Rank Amazon Fulfilled Prime Free Shipping
Pharmapacks 435
LY Berditchev Co. 56
The Perfect Deals 1,074
RGM GROUP 242
Aidleyco 2,964
A & H Supply 548
IDMACommerce 4,607

Features

Powerful nighttime relief: Orajel Maximum Strength Nighttime Toothache Pain Relief Cream provides maximum strength relief to alleviate toothache pain.
Targeted application: The cream is conveniently applied directly to the affected tooth and gum area, delivering fast-acting relief precisely where you need it most.
Show More
Top 9

Orajel, Instant Pain Relief Gel, Severe Toothache - 0.25 oz, 2 Pack

Orajel

Ratings for Orajel (CPR Score)

Seller CPR Rank Amazon Fulfilled Prime Free Shipping
Mr. Medical 82
Pharmapacks 435
The Mega Savings 4,315
Couger Energy 5,596
greenBulk 289

Features

It works immediately to deliver pain medication and lasts for hours, cooling and soothing the painful area.
Top 10

HURRICAINE Topical ANESTHETIC Liquid 20% 1OZ JAR Cherry

Hurricaine Cherry liquid
0.0625 Pounds

Ratings for Hurricaine Cherry liquid (CPR Score)

Seller CPR Rank Amazon Fulfilled Prime Free Shipping
JD DENTAL -
Health & Prime 358
Healing Easier 1,370
Casual Apparel Outlet -

Features

Numbs pain in the mouth
20% benzocaine gel
Show More

Benzodent Dental Pain Relieving Cream for Dentures and Braces, Topical Anesthetic, 0.25 Ounce Tube

Benzodent
10041167005320
3.75 x 1.06 x 3.13 Inches
0.0154 Pounds

Ratings for Benzodent (CPR Score)

Seller CPR Rank Amazon Fulfilled Prime Free Shipping
Amazon.com -

Features

FOR DENTAL PAIN: Benzodent provides temporary relief of pain for oral discomfort caused by dentures, braces or sores, with the maximum amount of benzocaine allowed in an over the counter oral product.
LONG LASTING RELIEF: Benzodent is a thick topical cream that provides pain relief with the strength of benzocaine. The unique formula cushions & adheres to gums for pain relief that lasts for hours.
Show More
Top 12

Safetec Oral Pain Relief.75 g Packets, Box of 144,85463

Safetec
85463
0.0149 Pounds

Ratings for Safetec (CPR Score)

Seller CPR Rank Amazon Fulfilled Prime Free Shipping
Amazon.com -
global-wholesale 7,311
Honest Medical 391
BI&R Basics 2,378

Features

package height : 16.992 cm
package length : 8.610 cm
Show More
Top 13

HurriCaine Topical Anesthetic Gel Watermelon - 1 oz.

Bobfriend

Ratings for Bobfriend (CPR Score)

Seller CPR Rank Amazon Fulfilled Prime Free Shipping
Preferred Pharmacy Plus 131
Quality Sourced Products 5,166
Health & Prime 358
Healing Easier 1,370
SupplyMedics -

Features

HurriCaine Topical Anesthetic Gel Watermelon - 1 oz.
Top 14

Orajel 2X Medicated Toothache & Mouth Sores Liquid, 0.45 Fl Oz

Orajel
7138Q
6.0 x 4.0 x 4.0 Inches
0.3 Pounds

Ratings for Orajel (CPR Score)

Seller CPR Rank Amazon Fulfilled Prime Free Shipping
Amazon.com -
The Mega Deals 1,271
KLC Bargains -

Features

20% Benzocaine to relieve oral pain
Menthol to soothe gums
Show More

DenTek Adult Instant Tooth Pain Relief Kit With 50 Applicators (Pack of 2)

DenTek
4.0 x 1.0 x 4.0 Inches
0.28 Pounds

Ratings for DenTek (CPR Score)

Seller CPR Rank Amazon Fulfilled Prime Free Shipping
Pharmapacks 435
LET'S BUY 991
GO SHOP INC -

Features

DenTek Instant Pain Relief, Advanced Kit gives instant and precise relief from oral pain and toothaches
Ergonomic handle to reach any area of the mouth gives simple, no-fingers no-mess, relief
Show More
Top 16

Rite Aid Toothache Relief Oral Gel - 0.42 oz

Rite Aid

Ratings for Rite Aid (CPR Score)

Seller CPR Rank Amazon Fulfilled Prime Free Shipping
Rite Aid, Inc. 136

Features

MOUTH SORE TREATMENT: Rite Aid Toothache & Gum Reliever Benzocaine 20% pain relieving liquid temporarily relieves pain associated with toothaches, sore gums, mouth sores, canker sores, dentures/braces, cheek bites, and minor dental procedures.
3X MEDICATED FAST-ACTING PAIN RELIEF: Rite Aid offers instant relief thanks to 3X medicated formula with Benzocaine, Astringent, and Menthol. Compare Rite Aid tooth pain relief to the leading national brand and get the same reliable mouth pain relief.
Show More

DenTek Canker Relief Sore Patch Relieves Canker Pain, 6 Count (Pack of 1)

DenTek

Ratings for DenTek (CPR Score)

Seller CPR Rank Amazon Fulfilled Prime Free Shipping
Amazon.com -
Primegoods2 -
Myreliablemart 4,257

Features

DenTek Canker Relief Advanced Canker Sore Patches help provide relief from canker sore pain and help protect from irritants while promoting healing
Clinically tested to reduce canker sore pain and help relieve the pain from small oral wounds and irritation from braces and oral ulcers
Show More
Top 18

Stopain Pain Relief Spray 4oz, USA Made, Max Strength Fast Acting with Menthol, MSM, Glucosamine for Lower Back, Arthritis, Knee, Neck, Joints, HSA FSA Approved OTC Topical Analgesic Product

Stopain
CS850-04
2.0 x 2.0 x 6.0 Inches
0.3542 Pounds

Ratings for Stopain (CPR Score)

Seller CPR Rank Amazon Fulfilled Prime Free Shipping
Amazon.com -
IthacaSports 6,617

Features

DOES WHAT IT SAYS – Stopain maximum strength products don’t just reduce or dull; our pain relieving spray STOPS your joint, muscle, and arthritis aches and pains fast
IMMEDIATE PENETRATING RELIEF - Soothing menthol topical analgesic free from dyes, fragrances, and preservatives, works on contact and is non-staining and non-greasy, non-irritating and non-allergenic
Show More
Top 19

Nyloxin Flavored Oral Spray Arthritis Pain Relief, Back Pain Relief, Neuropathy Pain Relief, Nerve Pain Relief, Knee Pain Relief, Foot Pain Relief, Muscle Pain Relief, Joint Pain Relief (1 oz)

Nyloxin

Ratings for Nyloxin (CPR Score)

Seller CPR Rank Amazon Fulfilled Prime Free Shipping
Nyloxin Chronic Pain Relief -

Features

MORE THAN A BACK PAIN RELIEF PRODUCT: Nyloxin works by using neuroactive peptides found in Asian cobra venom to provide inflammation relief, giving you real time pain relief.
ORAL SPRAY PAIN RELIEF: Nyloxin uses specialized proteins to block neurotransmitters responsible for signaling pain. Perfect for sciatic nerve pain relief, leg pain, sore muscle relief, hand pain, shingles pain relief, swollen feet relief.
Show More
Top 20

Rite Aid Severe Toothache and Gum Relief - 0.25 oz

Rite Aid
0.0156 Pounds

Ratings for Rite Aid (CPR Score)

Seller CPR Rank Amazon Fulfilled Prime Free Shipping
Rite Aid, Inc. 136

Features

MOUTH SORE TREATMENT: Rite Aid Severe Toothache & Gum Relief Benzocaine 20% pain relieving gel temporarily relieves pain associated with toothaches, sore gums, mouth sores, canker sores, dentures/braces, cheek bites, and minor dental procedures.
FAST-ACTING PAIN RELIEF: Rite Aid offers instant relief from pain associated with toothaches, gum pain, canker sores, and dentures/braces. Compare Rite Aid to the leading national brand and get the same reliable mouth pain relief you can count on.
Show More

Blistex Kanka Mouth Pain Liquid, Professional Strength , .33 Fluid Ounces

Kanka
41500
0.8 x 3.0 x 5.0 Inches

Ratings for Kanka (CPR Score)

Seller CPR Rank Amazon Fulfilled Prime Free Shipping
Royal Meds 115
Lava Vitality 733
SellLogic 6,258

Features

The Complete Solution for canker sores and other sores in the mouth
Maximum-strength pain medication (benzocaine) for fast temporary pain relief
Show More
Top 22

Kank-A Mouth Pain Liquid Professional Strength 0.33 oz (Pack of 3)

Blistex
SFS ONLY

Ratings for Blistex (CPR Score)

Seller CPR Rank Amazon Fulfilled Prime Free Shipping
Mr. Medical 82
Royal Meds 115
Otc Box -
Krish Pharm -

Features

FAST-ACTING RELIEF: Provides rapid relief from mouth pain, targeting the source of discomfort and soothing it in no time
MAXIMUM STRENGTH FORMULA: Formulated with a potent blend of active ingredients, ensures maximum strength to alleviate even the most severe oral discomfort
Show More

Orajel 3X for Toothache & Gum Pain: Maximum Gel Tube 0.42oz - From #1 Oral Pain Relief Brand - Orajel for Instant Pain Relief

Orajel
Orajel Maximum Strength Gel
1.0 x 4.375 x 3.75 Inches
0.04 Pounds

Ratings for Orajel (CPR Score)

Seller CPR Rank Amazon Fulfilled Prime Free Shipping
Amazon.com -
Vitabox 687
Cary's Store, LLC 6,966
ISKOLIVE 12 INC 1,704
K & B Corner LLC -
Playthings Aplenty LLC -

Features

INSTANT PAIN RELIEF: Instant pain relief with Orajel’s maximum strength formula to help relieve pain of the tooth and gums with 20% benzocaine
KILLS HARMFUL BACTERIA: Unique formula is designed to help kill harmful bacteria in the mouth, and can help to prevent infections
Show More
Top 24

Orajel Gel Regular 0.25 oz.

Orajel
CD22240
3.7 x 3.4 x 1.05 Inches

Ratings for Orajel (CPR Score)

Seller CPR Rank Amazon Fulfilled Prime Free Shipping
Moofin 298
Pharmapacks 435
westlake 187
BluebirdSales 2,810

Features

Orajel Gel regular 0.25 oz.

Orajel 4X for Toothache & Gum Pain Severe Gel Tube, No Color, 0.25 Ounce

Orajel
310310325039
1.0 x 3.188 x 3.75 Inches
0.016 Pounds

Ratings for Orajel (CPR Score)

Seller CPR Rank Amazon Fulfilled Prime Free Shipping
Amazon.com -
Mr. Medical 82
LY Berditchev Co. 56
Wiki Deals 53
MurMur Center 6,875
ISKOLIVE 12 INC 1,704
I Buy Direct 999

Features

Clinical Strength Pain Relief
Proven to Kill Harmful Bacteria
Show More
Top 26

Mavvel Yeegfeyuu Beutlich LP Pharmaceuticals Hurricaine Topical Anesthetic Gel, Piña Colada, 1 Ounce- Pack of 2

Mavvel
0.2205 Pounds

Ratings for Mavvel (CPR Score)

Seller CPR Rank Amazon Fulfilled Prime Free Shipping
JD DENTAL -
Healing Easier 1,370
Johnson Distributors 1,583
Top 27

Red Cross Toothache Complete Medication Kit 0.12 oz Pack of, 2 Count

Red Cross
6.0 x 6.0 x 10.0 Inches

Ratings for Red Cross (CPR Score)

Seller CPR Rank Amazon Fulfilled Prime Free Shipping
VerSure 26
Mr. Medical 82
Sebago Foods 140
E-Commodity -
greenBulk 289

Features

(picture may vary ) pack of 2 (184315)
Top 28

Orajel Medicated For Toothache Gel 0.25 Ounce (Pack of 6)

Orajel
1.0 x 3.188 x 3.75 Inches
0.036 Pounds

Ratings for Orajel (CPR Score)

Seller CPR Rank Amazon Fulfilled Prime Free Shipping
Amazon.com -
Ferebe 9,386
Ameretail 9,668
I Buy Direct 999
First Supplier NY -
KiwiC -

Features

10% Benzocaine to relieve oral pain
Provides Instant pain relief
Show More

Top 10 Oral Pain Relief Medications - Verified to Buy (Apr. 2024)

Top 10 Oral Pain Relief Medications Brands on Amazon

Here is the list of top-rated brands that were evaluated by CherryPicks.

  • Anbesol
  • DenTek
  • Safetec
  • Orajel
  • Benzodent
  • Red Cross
  • Hurricaine Cherry liquid
  • Bobfriend
  • Rite Aid
  • Stopain

Top 10 Oral Pain Relief Medications Sellers: CPR Seller Rank List

CPR sellers rank is based on CherryPicks-AI bestselling ranking system that helps us analyze each seller's sales trends. The List of top seller ranks is our in-house data, essential for our product ranking to help you make the right shopping choice.

Rank Name Yearly Feedbacks Avg. Ratings
🥇 VerSure 25,732 4.9
🥈 Wiki Deals 16,691 4.9
🥉 LY Berditchev Co. 16,122 4.9
4 Mr. Medical 13,973 4.9
5 Royal Meds 11,825 4.8
6 Preferred Pharmacy Plus 10,681 4.9
7 Rite Aid, Inc. 10,437 4.9
8 Sebago Foods 10,199 4.9
9 westlake 8,982 4.8
10 RGM GROUP 7,854 4.9
View or download top Oral Pain Relief Medications seller & rating report
VerSure [25732] Wiki Deals [16691] LY Berditchev Co. [16122] Mr. Medical [13973] Royal Meds [11825] Preferred Pharmacy Plus [10681] Rite Aid, Inc. [10437] Sebago Foods [10199] westlake [8982] RGM GROUP [7854] VerSure 19% Wiki Deals 13% LY Berditchev Co. 12% Mr. Medical 11% Royal Meds 9% Preferred Pharmacy Plus 8% Rite Aid, Inc. 8% Sebago Foods 8% westlake 7% RGM GROUP 6%

[Get] Oral Pain Relief Medications Deals (✅Exclusively for Prime)

What does "Amazon Fulfilled" Mean?

Amazon Fulfilled refers to products handled by Amazon's logistics, which indicates that the product is stored, packed, and shipped by Amazon from one of its fulfillment centers.

When you order a product that is "Amazon Fulfilled," Amazon takes care of the storage, packing, shipping, and customer service for that product. This often ensures quicker delivery and better customer service compared to products that are not fulfilled by Amazon. It also means that the product is eligible for Amazon's return policy.

What does "Prime" Mean?

"Prime" refers to Amazon Prime Member (Join Amazon Prime Now), which indicates eligibility for Prime benefits. When you see "Prime" next to a product on Amazon, This generally means that if you are  an Amazon Prime member, you can get free two-day shipping on that product, and sometimes even same-day or one-day shipping depending on your location.

Prime members also have access to other benefits, including 2-Day ShippingExclusive Member DealsPrime VideoBuy With PrimeAmazon MusicPrime Gaming, and more.

Shop Prime Oral Pain Relief Medications Deals

What does "Free Shipping" Mean?

"Free Shipping" means that you will not be charged additional fees for the shipping of that product. However, unlike "Prime," which usually guarantees fast two-day shipping, "Free Shipping" doesn't necessarily mean fast shipping.

Sometimes there might be a minimum purchase requirement to qualify for free shipping if you are not a Prime member. For Prime members, the "Free Shipping" usually refers to the free two-day shipping that is one of the benefits of the Prime membership.


Why Should You Trust Us?

Now hundreds and thousands of Oral Care supplies are available on Amazon, Picking the right one is not easy, and that may take a lot of your time, Right? and What is the best Oral Pain Relief Medications to buy for new December 2024?

CherryPicks’s Methodology for Evaluating Oral Pain Relief Medications

We developed the CherryRatings-AI system to identify and score reviews and the CherryPicks-AI ranking system that uses TensorFlow framework to generate the best list, It will help us evaluate Oral Care items that sell on Amazon. The score of items is based on over ten parameters such as analyzing customer review content, product reviewing rating statistics, brand reputation evaluation, comparing product price with features, etc, You can visit How We Rank to learn more in detail.

We collected and analyzed 93 of Oral Pain Relief Medications reviews based on our selection criteria. It helped us shortlist the top qualified and rated Oral Pain Relief Medications for Oral Care, We found that most customers choose Oral Pain Relief Medications with an average price of $13.12, and the top brands are DenTek, Orajel, Rite Aid, Blistex, Stopain, Anbesol, Benzodent, Red Cross, Safetec, LIUMY, Mavvel, Kanka, Bobfriend, Hurricaine Cherry liquid, Nyloxin And Tisserand. 

Then our expert-level editors reviewed all those quality items and selected the top 28 Oral Pain Relief Medications for you, We have researched hundreds of sellers and picked the top sellers for Oral Care, including VerSure, Wiki Deals, LY Berditchev Co., Mr. Medical, Royal Meds, Preferred Pharmacy Plus, Rite Aid, Inc., Sebago Foods, westlake, RGM GROUP, greenBulk And Moofin. The Anbesol Maximum Strength Oral Pain Relief Gel, ... are available for purchase right now, and The seller of #1 rank product has received honest feedback from 14,029 consumers with an average rating of 4.6.

We've helped a lot of satisfied users get the right Health & Household product based on their needs, and save lots of time for them to pick Oral Pain Relief Medications to buy.


Written By Dr. Daniel Awesome

Daniel is a part-time writer on the platform as he has got a full-time job as a practicing medical doctor. When he is free, he share with us, his knowledge about health and well being. He is your plug if you are interested in healthy living habits.